PDBe 3fia

X-ray diffraction
1.45Å resolution

Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.

Released:
Source organism: Homo sapiens
Entry authors: Vorobiev SM, Chen Y, Seetharaman J, Devices C, Zhao L, Foote EL, Ciccosanti C, Mao L, Xiao R, Acton TB, Montelione GT, Hunt JF, Tong L, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intersectin-1 Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15811 (Residues: 1-111; Coverage: 6%)
Gene names: ITSN, ITSN1, SH3D1A
Sequence domains: Cytoskeletal-regulatory complex EF hand
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2
Unit cell:
a: 94.848Å b: 32.021Å c: 33.287Å
α: 90° β: 106.45° γ: 90°
R-values:
R R work R free
0.16 0.16 0.176
Expression system: Escherichia coli