PDBe 3fi8

X-ray diffraction
2.3Å resolution

Crystal structure of choline kinase from Plasmodium Falciparum, PF14_0020

Released:
Source organism: Plasmodium falciparum 3D7
Entry authors: Wernimont AK, Pizarro JC, Artz JD, Amaya MF, Xiao T, Lew J, Wasney G, Senesterra G, Kozieradzki I, Cossar D, Vedadi M, Schapira M, Bochkarev A, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Hui R, Hills T, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline kinase Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 43.06 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IM71 (Residues: 79-440; Coverage: 82%)
Gene names: PF14_0020, PF3D7_1401800
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 58.38Å b: 64.556Å c: 91.557Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.265
Expression system: Escherichia coli