PDBe 3fhb

X-ray diffraction
2.3Å resolution

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid


Function and Biology Details

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Poly [ADP-ribose] polymerase 3 Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 39.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y6F1 (Residues: 178-532; Coverage: 67%)
Gene names: ADPRT3, ADPRTL3, PARP3
Sequence domains: Poly(ADP-ribose) polymerase, regulatory domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 55.24Å b: 56.7Å c: 56.48Å
α: 90° β: 112.86° γ: 90°
R R work R free
0.182 0.178 0.254
Expression system: Escherichia coli