PDBe 3feg

X-ray diffraction
1.3Å resolution

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

Released:

Function and Biology Details

Reactions catalysed:
ATP + choline = ADP + phosphocholine. 
ATP + ethanolamine = ADP + O-phosphoethanolamine. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline/ethanolamine kinase Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y259 (Residues: 35-395; Coverage: 91%)
Gene names: CHETK, CHKB, CHKL
Sequence domains: Choline/ethanolamine kinase
Structure domains: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 97.994Å b: 72.987Å c: 62.397Å
α: 90° β: 117.76° γ: 90°
R-values:
R R work R free
0.16 0.158 0.193
Expression system: Escherichia coli