PDBe 3fe3

X-ray diffraction
1.9Å resolution

Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant

Released:
Source organism: Homo sapiens
Entry authors: Nugoor C, Marx A, Panneerselvam S, Mandelkow E-M, Mandelkow E

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP/microtubule affinity-regulating kinase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27448 (Residues: 41-367; Coverage: 43%)
Gene names: CTAK1, EMK2, MARK3
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: C2
Unit cell:
a: 96.52Å b: 95.33Å c: 111.08Å
α: 90° β: 106.39° γ: 90°
R-values:
R R work R free
0.199 0.197 0.233
Expression system: Escherichia coli