PDBe 3fc1

X-ray diffraction
2.4Å resolution

Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: X
Molecule details ›
Chain: X
Length: 366 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 45.697Å b: 85.958Å c: 123.271Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.199 0.251
Expression system: Trichoplusia ni