PDBe 3f9n

X-ray diffraction
1.9Å resolution

Crystal structure of chk1 kinase in complex with inhibitor 38

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 322 amino acids
Theoretical weight: 36.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14757 (Residues: 2-307; Coverage: 64%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 45.06Å b: 65.75Å c: 58.41Å
α: 90° β: 96.24° γ: 90°
R-values:
R R work R free
0.184 0.182 0.216
Expression system: Spodoptera frugiperda