PDBe 3f88

X-ray diffraction
2.6Å resolution

glycogen synthase Kinase 3beta inhibitor complex


Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + [tau protein] = ADP + [tau protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 349 amino acids
Theoretical weight: 39.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P49841 (Residues: 35-383; Coverage: 83%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 66.947Å b: 111.785Å c: 66.955Å
α: 90° β: 100.84° γ: 90°
R R work R free
0.204 0.199 0.281
Expression system: Spodoptera frugiperda