PDBe 3f69

X-ray diffraction
2.8Å resolution

Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PknB Chains: A, B
Molecule details ›
Chains: A, B
Length: 311 amino acids
Theoretical weight: 33.55 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WI81 (Residues: 1-308; Coverage: 49%)
Gene names: MTCY10H4.14c, Rv0014c, pknB
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: F4132
Unit cell:
a: 297.557Å b: 297.557Å c: 297.557Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.268
Expression system: Escherichia coli