› 3f5v

X-ray diffraction
1.36Å resolution

Function and Biology Details

Reaction catalysed: 
Broad endopeptidase specificity
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Der p 1 allergen Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 25.06 KDa
Source organism: Dermatophagoides pteronyssinus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q3HWZ5 (Residues: 81-302; Coverage: 74%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand P6G 5 x P6G
1 modified residue:
Ligand CSD 2 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 95.196Å b: 84.07Å c: 75.437Å
α: 90° β: 123.81° γ: 90°
R-values:
R R work R free
0.159 0.158 0.183
Expression system: Komagataella pastoris

Quick links

Citations

15 review citations

Allergens and their role in the allergic immune response.
Platts-Mills et al. (2011)
14 more

9 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
8 more