PDBe 3f5c

X-ray diffraction
3Å resolution

Structure of Dax-1:LRH-1 complex

Released:
Source organism: Mus musculus
Primary publication:
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Proc. Natl. Acad. Sci. U.S.A. 105 18390-5 (2008)
PMID: 19015525

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 0 group B member 1 Chains: B, C
Molecule details ›
Chains: B, C
Length: 268 amino acids
Theoretical weight: 30.38 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61066 (Residues: 205-472; Coverage: 57%)
Gene names: Ahch, Dax1, Nr0b1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 5 group A member 2 Chain: A
Molecule details ›
Chain: A
Length: 248 amino acids
Theoretical weight: 28.73 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45448 (Residues: 313-560; Coverage: 44%)
Gene names: Lrh1, Nr5a2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P43
Unit cell:
a: 103.355Å b: 103.355Å c: 117.455Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.279
Expression system: Escherichia coli