PDBe 3f3z

X-ray diffraction
1.84Å resolution

Crystal structure of Cryptosporidium parvum calcium dependent protein kinase cgd7_1840 in presence of indirubin E804

Released:
Entry authors: Wernimont AK, Lew J, Wasney G, Kozieradzki I, Cossar D, Vedadi M, Bochkarev A, Arrowsmith CH, Sundstrom M, Weigelt J, Edwards AM, Hui R, Artz JD, Amani M, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.95 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CYL9 (Residues: 197-472; Coverage: 41%)
Gene name: cgd7_1840
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 63.316Å b: 82.864Å c: 62.151Å
α: 90° β: 111.61° γ: 90°
R-values:
R R work R free
0.189 0.187 0.23
Expression system: Escherichia coli