PDBe 3f3t

X-ray diffraction
2.5Å resolution

Kinase domain of cSrc in complex with inhibitor RL38 (Type III)

Released:
Source organism: Gallus gallus
Primary publication:
A new screening assay for allosteric inhibitors of cSrc.
Nat. Chem. Biol. 5 394-6 (2009)
PMID: 19396179

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.74 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 42.01Å b: 63.49Å c: 74.99Å
α: 78.71° β: 89.71° γ: 89.91°
R-values:
R R work R free
0.246 0.244 0.295
Expression system: Escherichia coli