PDBe 3eyg

X-ray diffraction
1.9Å resolution

Crystal structures of JAK1 and JAK2 inhibitor complexes

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK1 Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 33.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23458 (Residues: 865-1154; Coverage: 25%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2221
Unit cell:
a: 45.025Å b: 88.218Å c: 145.834Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.214
Expression system: Escherichia coli