Function and Biology Details
Reaction catalysed:
Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thiamin diphosphate-binding fold
- TPP-binding enzyme, conserved site
- Thiamine pyrophosphate enzyme, TPP-binding
- Pyruvate oxidase POXB-like, PP-binding domain
- Thiamine pyrophosphate enzyme, central domain
- DHS-like NAD/FAD-binding domain superfamily
- Pyruvate oxidase POXB-like, pyrimidine-binding domain
- Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
2 more domains
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
Pyruvate dehydrogenase [ubiquinone] (preferred)
PDBe Complex ID:
PDB-CPX-139335 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate dehydrogenase [ubiquinone]
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 549 amino acids
Theoretical weight: 59.46 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 549 amino acids
Theoretical weight: 59.46 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
- Canonical:
P07003 (Residues: 1-549; Coverage: 96%)
Sequence domains:
- Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
- Thiamine pyrophosphate enzyme, central domain
- Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
