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Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

Source organism: Homo sapiens
Biochemical function: pyruvate dehydrogenase (NAD+) activity
Biological process: tricarboxylic acid cycle
Cellular component: pyruvate dehydrogenase complex

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EC 1.2.4.1: Pyruvate dehydrogenase (acetyl-transferring)

Reaction catalysed:
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2)
Systematic name:
Pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Alternative Name(s):
  • PDH
  • Pyruvate decarboxylase
  • Pyruvate dehydrogenase
  • Pyruvate dehydrogenase (lipoamide)
  • Pyruvate dehydrogenase complex
  • Pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating)
  • Pyruvic acid dehydrogenase
  • Pyruvic dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02780
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
The deposited structure of PDB entry 3exg contains 16 copies of Pfam domain PF02780 (Transketolase, C-terminal domain) in Pyruvate dehydrogenase E1 component subunit beta, mitochondrial. Showing 1 copy in chain BA [auth 2].

PF02779
Domain description: Transketolase, pyrimidine binding domain
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
The deposited structure of PDB entry 3exg contains 16 copies of Pfam domain PF02779 (Transketolase, pyrimidine binding domain) in Pyruvate dehydrogenase E1 component subunit beta, mitochondrial. Showing 1 copy in chain BA [auth 2].

PF00676
Domain description: Dehydrogenase E1 component
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
The deposited structure of PDB entry 3exg contains 16 copies of Pfam domain PF00676 (Dehydrogenase E1 component) in Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial. Showing 1 copy in chain M.

InterPro InterPro annotations
IPR009014
Domain description: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
IPR005475
Domain description: Transketolase-like, pyrimidine-binding domain
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  2. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
IPR033248
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
IPR027110
Domain description: Pyruvate dehydrogenase E1 component subunit beta
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
IPR001017
Domain description: Dehydrogenase, E1 component
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
IPR017597
Domain description: Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Structure domains

CATH CATH domains
3.40.50.970
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  2. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
The deposited structure of PDB entry 3exg contains 16 copies of CATH domain 3.40.50.970 (Rossmann fold) in Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial. Showing 1 copy in chain E.
The deposited structure of PDB entry 3exg contains 16 copies of CATH domain 3.40.50.970 (Rossmann fold) in Pyruvate dehydrogenase E1 component subunit beta, mitochondrial. Showing 1 copy in chain BA [auth 2].
3.40.50.920
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
The deposited structure of PDB entry 3exg contains 16 copies of CATH domain 3.40.50.920 (Rossmann fold) in Pyruvate dehydrogenase E1 component subunit beta, mitochondrial. Showing 1 copy in chain BA [auth 2].

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