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Crystal structure of PYK2 complexed with PF-2318841

X-ray diffraction
2.7Å resolution
PDB entry 3et7 coloured by chain, front view.
PDB entry 3et7 coloured by chain, side view.
PDB entry 3et7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein-tyrosine kinase 2-beta
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Multimeric state: monomeric
Accessible surface area: 13464.26 Å2
Buried surface area: 163.21 Å2
Dissociation area: 81.6 Å2
Dissociation energy (ΔGdiss): 3.78 kcal/mol
Dissociation entropy (TΔSdiss): 0.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171983

Macromolecules

Protein-tyrosine kinase 2-beta
Chain: A
Length: 277 amino acids
Theoretical weight: 32.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14289 (Residues: 416-692; Coverage: 28%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Protein-tyrosine kinase 2-beta in PDB entry 3et7, assembly 1, front view.
Protein-tyrosine kinase 2-beta in PDB entry 3et7, assembly 1, side view.
Protein-tyrosine kinase 2-beta in PDB entry 3et7, assembly 1, top view.
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