PDBe 3eqr

X-ray diffraction
2Å resolution

Crystal Structure of Ack1 with compound T74

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated CDC42 kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.54 KDa
Source organism: Homo sapiens
Expression system: Insect cells
UniProt:
  • Canonical: Q07912 (Residues: 117-392; Coverage: 27%)
Gene names: ACK1, TNK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 70.785Å b: 42.915Å c: 92.832Å
α: 90° β: 99.67° γ: 90°
R-values:
R R work R free
0.212 0.21 0.256
Expression system: Insect cells