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The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.

Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C
J. Biol. Chem. 286 15344-51 (2011)
Cited: 73 times
EuropePMC logo PMID: 21389349

Reviews - 3epz mentioned but not cited (1)

  1. Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives. Andreoli F, Barbosa AJ, Parenti MD, Del Rio A. Curr. Pharm. Des. 19 578-613 (2013)

Articles - 3epz mentioned but not cited (9)

  1. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Klein CJ, Botuyan MV, Wu Y, Ward CJ, Nicholson GA, Hammans S, Hojo K, Yamanishi H, Karpf AR, Wallace DC, Simon M, Lander C, Boardman LA, Cunningham JM, Smith GE, Litchy WJ, Boes B, Atkinson EJ, Middha S, B Dyck PJ, Parisi JE, Mer G, Smith DI, Dyck PJ. Nat. Genet. 43 595-600 (2011)
  2. DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination. Qin W, Wolf P, Liu N, Link S, Smets M, La Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H, Leonhardt H. Cell Res. 25 911-929 (2015)
  3. Minimal functional sites allow a classification of zinc sites in proteins. Andreini C, Bertini I, Cavallaro G. PLoS ONE 6 e26325 (2011)
  4. The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1. Syeda F, Fagan RL, Wean M, Avvakumov GV, Walker JR, Xue S, Dhe-Paganon S, Brenner C. J. Biol. Chem. 286 15344-15351 (2011)
  5. DNA methyl transferase 1: regulatory mechanisms and implications in health and disease. Dhe-Paganon S, Syeda F, Park L. Int J Biochem Mol Biol 2 58-66 (2011)
  6. DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated? Maresca A, Zaffagnini M, Caporali L, Carelli V, Zanna C. Front Genet 6 90 (2015)
  7. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
  8. The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast. White SA, Buscaino A, Sanchez-Pulido L, Ponting CP, Nowicki MW, Allshire RC. PLoS ONE 9 e104161 (2014)
  9. Anti-Colon Cancer Activity of Dietary Phytochemical Soyasaponin I and the Induction of Metabolic Shifts in HCT116. Xia X, Lin Q, Zhao N, Zeng J, Yang J, Liu Z, Huang R. Molecules 27 4382 (2022)


Reviews citing this publication (20)

  1. Interpreting the language of histone and DNA modifications. Rothbart SB, Strahl BD. Biochim. Biophys. Acta 1839 627-643 (2014)
  2. Understanding the relationship between DNA methylation and histone lysine methylation. Rose NR, Klose RJ. Biochim. Biophys. Acta 1839 1362-1372 (2014)
  3. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, Blackledge NP, Klose RJ. Biochem. Soc. Trans. 41 727-740 (2013)
  4. Epigenetics of sleep and chronobiology. Qureshi IA, Mehler MF. Curr Neurol Neurosci Rep 14 432 (2014)
  5. Structural and functional coordination of DNA and histone methylation. Cheng X. Cold Spring Harb Perspect Biol 6 (2014)
  6. Mammalian epigenetic mechanisms. Zhang G, Pradhan S. IUBMB Life 66 240-256 (2014)
  7. Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm. Jeltsch A, Jurkowska RZ. Nucleic Acids Res. 44 8556-8575 (2016)
  8. Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum". Noh KM, Allis CD, Li H. ACS Chem. Biol. 11 554-563 (2016)
  9. Genomic imprinting--the struggle of the genders at the molecular level. Jurkowska RZ, Jeltsch A. Angew. Chem. Int. Ed. Engl. 52 13524-13536 (2013)
  10. Mammalian DNA methyltransferases: new discoveries and open questions. Gowher H, Jeltsch A. Biochem. Soc. Trans. 46 1191-1202 (2018)
  11. Target specificity of mammalian DNA methylation and demethylation machinery. Ravichandran M, Jurkowska RZ, Jurkowski TP. Org. Biomol. Chem. 16 1419-1435 (2018)
  12. On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver. Benetatos L, Vartholomatos G. Ann. Hematol. 95 1571-1582 (2016)
  13. Computer-Aided Drug Design in Epigenetics. Lu W, Zhang R, Jiang H, Zhang H, Luo C. Front Chem 6 57 (2018)
  14. Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy. Rondelet G, Wouters J. Biochimie 139 137-147 (2017)
  15. DNA methyltransferases and gastric cancer: insight into targeted therapy. Fattahi S, Golpour M, Amjadi-Moheb F, Sharifi-Pasandi M, Khodadadi P, Pilehchian-Langroudi M, Ashrafi GH, Akhavan-Niaki H. Epigenomics 10 1477-1497 (2018)
  16. Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns. Bronner C, Alhosin M, Hamiche A, Mousli M. Genes (Basel) 10 (2019)
  17. DNA methyltransferase-1 in acute myeloid leukaemia: beyond the maintenance of DNA methylation. Li M, Zhang D. Ann Med 54 2011-2023 (2022)
  18. Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns. Nai YS, Huang YC, Yen MR, Chen PY. Front Microbiol 11 616922 (2020)
  19. Evolution of CG Methylation Maintenance Machinery in Plants. Tirot L, Jullien PE, Ingouff M. Epigenomes 5 19 (2021)
  20. Mechanisms of chromatin-based epigenetic inheritance. Du W, Shi G, Shan CM, Li Z, Zhu B, Jia S, Li Q, Zhang Z. Sci China Life Sci 65 2162-2190 (2022)

Articles citing this publication (43)

  1. Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X. Nucleic Acids Res. 40 4841-4849 (2012)
  2. The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA. Berkyurek AC, Suetake I, Arita K, Takeshita K, Nakagawa A, Shirakawa M, Tajima S. J. Biol. Chem. 289 379-386 (2014)
  3. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. Bashtrykov P, Jankevicius G, Jurkowska RZ, Ragozin S, Jeltsch A. J. Biol. Chem. 289 4106-4115 (2014)
  4. Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1. Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C. Biochem. Biophys. Res. Commun. 430 208-212 (2013)
  5. DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss. Klein CJ, Bird T, Ertekin-Taner N, Lincoln S, Hjorth R, Wu Y, Kwok J, Mer G, Dyck PJ, Nicholson GA. Neurology 80 824-828 (2013)
  6. Crystal Structure of Human DNA Methyltransferase 1. Zhang ZM, Liu S, Lin K, Luo Y, Perry JJ, Wang Y, Song J. J. Mol. Biol. 427 2520-2531 (2015)
  7. Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. Fagan RL, Cryderman DE, Kopelovich L, Wallrath LL, Brenner C. J. Biol. Chem. 288 23858-23867 (2013)
  8. Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE. Yuan J, Higuchi Y, Nagado T, Nozuma S, Nakamura T, Matsuura E, Hashiguchi A, Sakiyama Y, Yoshimura A, Takashima H. J. Peripher. Nerv. Syst. 18 89-93 (2013)
  9. Twists and turns of DNA methylation. Frauer C, Leonhardt H. Proc. Natl. Acad. Sci. U.S.A. 108 8919-8920 (2011)
  10. New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors. Gros C, Fleury L, Nahoum V, Faux C, Valente S, Labella D, Cantagrel F, Rilova E, Bouhlel MA, David-Cordonnier MH, Dufau I, Ausseil F, Mai A, Mourey L, Lacroix L, Arimondo PB. J. Biol. Chem. 290 6293-6302 (2015)
  11. RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis. Huang J, Stewart A, Maity B, Hagen J, Fagan RL, Yang J, Quelle DE, Brenner C, Fisher RA. Oncogene 33 3604-3611 (2014)
  12. Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain. Bashtrykov P, Rajavelu A, Hackner B, Ragozin S, Carell T, Jeltsch A. Chembiochem 15 743-748 (2014)
  13. RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation. Wu BK, Mei SC, Brenner C. Cell Cycle 13 3222-3231 (2014)
  14. Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation. Li T, Wang L, Du Y, Xie S, Yang X, Lian F, Zhou Z, Qian C. Nucleic Acids Res. 46 3218-3231 (2018)
  15. An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes. Fagan RL, Wu M, Chédin F, Brenner C. PLoS ONE 8 e78752 (2013)
  16. DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. Smets M, Link S, Wolf P, Schneider K, Solis V, Ryan J, Meilinger D, Qin W, Leonhardt H. Hum. Mol. Genet. 26 1522-1534 (2017)
  17. Placental mesenchymal stem cells of fetal origin deposit epigenetic alterations during long-term culture under serum-free condition. Zhu Y, Song X, Wang J, Li Y, Yang Y, Yang T, Ma H, Wang L, Zhang G, Cho WC, Liu X, Wei J. Expert Opin Biol Ther 15 163-180 (2015)
  18. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, Mulholland CB, Bultmann S, Kori S, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M. Nat Commun 11 1222 (2020)
  19. Comment DNMT1-associated DNA methylation changes in cancer. Bashtrykov P, Jeltsch A. Cell Cycle 14 5 (2015)
  20. DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Ren W, Fan H, Grimm SA, Kim JJ, Li L, Guo Y, Petell CJ, Tan XF, Zhang ZM, Coan JP, Yin J, Kim DI, Gao L, Cai L, Khudaverdyan N, Çetin B, Patel DJ, Wang Y, Cui Q, Strahl BD, Gozani O, Miller KM, O'Leary SE, Wade PA, Wang GG, Song J. Nat Commun 12 2490 (2021)
  21. Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation. Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M. Sci Rep 7 55 (2017)
  22. The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition. Misaki T, Yamaguchi L, Sun J, Orii M, Nishiyama A, Nakanishi M. Biochem. Biophys. Res. Commun. 470 741-747 (2016)
  23. Selection and Characterization of Mutants Defective in DNA Methylation in Neurospora crassa. Klocko AD, Summers CA, Glover ML, Parrish R, Storck WK, McNaught KJ, Moss ND, Gotting K, Stewart A, Morrison AM, Payne L, Hatakeyama S, Selker EU. Genetics 216 671-688 (2020)
  24. Cyclic DNA remethylation following active demethylation at euchromatic regions in mouse embryonic stem cells. Kubiura-Ichimaru M, Ito T, Lefebvre L, Tada M. Chromosome Res 29 145-157 (2021)
  25. Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Ren W, Fan H, Grimm SA, Guo Y, Kim JJ, Yin J, Li L, Petell CJ, Tan XF, Zhang ZM, Coan JP, Gao L, Cai L, Detrick B, Çetin B, Cui Q, Strahl BD, Gozani O, Wang Y, Miller KM, O'Leary SE, Wade PA, Patel DJ, Wang GG, Song J. Proc Natl Acad Sci U S A 117 18439-18447 (2020)
  26. Misregulation of the expression and activity of DNA methyltransferases in cancer. Mensah IK, Norvil AB, AlAbdi L, McGovern S, Petell CJ, He M, Gowher H. NAR Cancer 3 zcab045 (2021)
  27. Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1. Lamiable-Oulaidi F, Harijan RK, Shaffer KJ, Crump DR, Sun Y, Du Q, Gulab SA, Khan AA, Luxenburger A, Woolhouse AD, Sidoli S, Tyler PC, Schramm VL. J Med Chem 65 5462-5494 (2022)
  28. The C-terminal D/E-rich domain of MBD3 is a putative Z-DNA mimic that competes for Zα DNA-binding activity. Lee CH, Shih YP, Ho MR, Wang AH. Nucleic Acids Res. 46 11806-11821 (2018)
  29. Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s. Liang Z, Zhu Y, Long J, Ye F, Hu G. Comput Struct Biotechnol J 18 749-764 (2020)
  30. Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1. Kanada K, Takeshita K, Suetake I, Tajima S, Nakagawa A. J. Biochem. 162 271-278 (2017)
  31. Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1. Switzer RL, Hartman ZJ, Hewett GR, Carroll CF. DNA (Basel) 3 119-133 (2023)
  32. Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases. Tajima S, Suetake I, Takeshita K, Nakagawa A, Kimura H, Song J. Adv Exp Med Biol 1389 45-68 (2022)
  33. Enzymology of Mammalian DNA Methyltransferases. Jurkowska RZ, Jeltsch A. Adv Exp Med Biol 1389 69-110 (2022)
  34. Exploration of cell cycle regulation and modulation of the DNA methylation mechanism of pelargonidin: Insights from the molecular modeling approach. Karthi N, Karthiga A, Kalaiyarasu T, Stalin A, Manju V, Singh SK, Cyril R, Lee SM. Comput Biol Chem 70 175-185 (2017)
  35. Extensions to Michaelis-Menten Kinetics for Single Parameters. Ariyawansha RTK, Basnayake BFA, Karunarathna AK, Mowjood MIM. Sci Rep 8 16586 (2018)
  36. Isoform-resolved transcriptome of the human preimplantation embryo. Torre D, Francoeur NJ, Kalma Y, Gross Carmel I, Melo BS, Deikus G, Allette K, Flohr R, Fridrikh M, Vlachos K, Madrid K, Shah H, Wang YC, Sridhar SH, Smith ML, Eliyahu E, Azem F, Amir H, Mayshar Y, Marazzi I, Guccione E, Schadt E, Ben-Yosef D, Sebra R. Nat Commun 14 6902 (2023)
  37. KRAS-driven miR-29b expression is required for tumor suppressor gene silencing. Thakur S, Brenner C. Oncotarget 8 74755-74766 (2017)
  38. Mechanism studies of the activation of DNA methyltransferase DNMT1 triggered by histone H3 ubiquitination, revealed by multi-scale molecular dynamics simulations. Sun J, Liu F, Yuan L, Pang NN, Zhu B, Yang N. Sci China Life Sci (2022)
  39. RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails. Mishima Y, Brueckner L, Takahashi S, Kawakami T, Arita K, Oka S, Otani J, Hojo H, Shirakawa M, Shinohara A, Watanabe M, Suetake I. FEBS J. 284 3455-3469 (2017)
  40. Structure and Mechanism of Plant DNA Methyltransferases. Leichter SM, Du J, Zhong X. Adv Exp Med Biol 1389 137-157 (2022)
  41. Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors. Switzer RL, Medrano J, Reedel DA, Weiss J. PLoS ONE 14 e0219830 (2019)
  42. The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation. Bhogal B, Weir BA, Crescenzo R, Marien A, Kwon MC, Philippar U, Cowley GS. Commun Biol 5 1174 (2022)
  43. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Miyashita R, Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, Nakanishi M. Elife 12 e79013 (2023)


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