Structure analysis

Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor

X-ray diffraction
2.66Å resolution
Source organism: Gallus gallus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 12000 Å2
Buried surface area: 750 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Interface energy (ΔGint): -5 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

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