PDBe 3elj

X-ray diffraction
1.8Å resolution

Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 8 Chain: A
Molecule details ›
Chain: A
Length: 369 amino acids
Theoretical weight: 42.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45983 (Residues: 1-364; Coverage: 85%)
Gene names: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 50.745Å b: 71.465Å c: 108.692Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.215
Expression system: Escherichia coli