PDBe 3el8

X-ray diffraction
2.3Å resolution

Crystal structure of c-Src in complex with pyrazolopyrimidine 5

Source organism: Gallus gallus
Primary publication:
Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chem. Biol. 15 1015-22 (2008)
PMID: 18940662

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P1
Unit cell:
a: 42.375Å b: 63.693Å c: 73.792Å
α: 101.01° β: 90.25° γ: 90.12°
R R work R free
0.218 0.218 0.262
Expression system: Escherichia coli BL21