PDBe 3el7

X-ray diffraction
2.8Å resolution

Crystal structure of c-Src in complex with pyrazolopyrimidine 3

Source organism: Gallus gallus
Primary publication:
Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chem. Biol. 15 1015-22 (2008)
PMID: 18940662

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 42.36Å b: 63.13Å c: 56.05Å
α: 90° β: 91.9° γ: 90°
R R work R free
0.22 0.22 0.288
Expression system: Escherichia coli BL21