› 3ebm

X-ray diffraction
2.6Å resolution

Crystal structure of human translationally controlled tumour associated protein (hTCTP) mutant E12V

Released:
DOI: 10.2210/pdb3ebm/pdb
PDB entry 3ebm coloured by chain, front view.
PDB entry 3ebm coloured by chain, side view.
PDB entry 3ebm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein.
Dong X, Yang B, Li Y, Zhong C, Ding J
J Biol Chem 284 23754-64 (2009)
PMID: 19570981

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146705 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translationally-controlled tumor protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 180 amino acids
Theoretical weight: 20.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13693 (Residues: 1-172; Coverage: 100%)
Gene name: TPT1
Sequence domains: Translationally controlled tumour protein
Structure domains: Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 78.192Å b: 81.543Å c: 139.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.28
Expression system: Escherichia coli

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Citations

12 review citations

Regulation of mTORC1 by PI3K signaling.
Dibble et al. (2015)
11 more

5 mentions without citation

Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein.
Dong et al. (2009)
4 more