PDBe 3eb0

X-ray diffraction
2.65Å resolution

Crystal Structure of cgd4_240 from cryptosporidium Parvum in complex with indirubin E804

Released:
Entry authors: Wernimont AK, Fedorov O, Lam A, Ali A, Zhao Y, Lew J, Wasney G, Vedadi M, Kozieradzki I, Schapira M, Bochkarev A, Wilstrom M, Bountra C, Arrowsmith CH, Edwards AM, Hui R, Lin YH, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative uncharacterized protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 383 amino acids
Theoretical weight: 43.83 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: A3FQN0 (Residues: 52-433; Coverage: 88%)
Gene name: cgd4_240
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 134.101Å b: 138.366Å c: 43.261Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.295
Expression system: Escherichia coli