PDBe 3e92

X-ray diffraction
2Å resolution

Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
Kinase array design, back to front: biaryl amides.
Bioorg. Med. Chem. Lett. 18 5285-9 (2008)
PMID: 18789685

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 42.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 45.516Å b: 86.224Å c: 124.191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.216
Expression system: Escherichia coli