› › Function and Biology

Crystal structure of Thymidine Kinase from S. aureus

Source organism: Staphylococcus aureus
Biochemical function: metal ion binding
Biological process: DNA biosynthetic process
Cellular component: cytosol

Quick links

EC 2.7.1.21: Thymidine kinase

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Systematic name:
ATP:thymidine 5'-phosphotransferase
Alternative Name(s):
  • 2'-deoxythymidine kinase
  • Deoxythymidine kinase (phosphorylating)
  • Thymidine kinase (phosphorylating)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00265
Domain description: Thymidine kinase
Occurring in:
  1. Thymidine kinase
The deposited structure of PDB entry 3e2i contains 1 copy of Pfam domain PF00265 (Thymidine kinase) in Thymidine kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001267
Domain description: Thymidine kinase
Occurring in:
  1. Thymidine kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Thymidine kinase
IPR020633
Domain description: Thymidine kinase, conserved site
Occurring in:
  1. Thymidine kinase

Structure domains

CATH CATH domains
3.30.60.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Thymidine kinase
The deposited structure of PDB entry 3e2i contains 1 copy of CATH domain 3.30.60.20 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Thymidine kinase. Showing 1 copy in chain A.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Thymidine kinase
The deposited structure of PDB entry 3e2i contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Thymidine kinase. Showing 1 copy in chain A.

Quick links