PDBe 3e2i

X-ray diffraction
2.01Å resolution

Crystal structure of Thymidine Kinase from S. aureus

Released:
Source organism: Staphylococcus aureus
Entry authors: Lam R, Johns K, Battaile KP, Romanov V, Lam K, Pai EF, Chirgadze NY

Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.75 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0H0G9 (Residues: 1-199; Coverage: 100%)
Gene names: CEJ93_11100, ERS072738_01928, ERS072840_01851, ERS074020_01889, tdk
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P4222
Unit cell:
a: 71.621Å b: 71.621Å c: 96.144Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.237
Expression system: Escherichia coli