Function and Biology

Human AdoMetDC with 5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine

Source organism: Homo sapiens
Biochemical function: adenosylmethionine decarboxylase activity
Biological process: spermidine biosynthetic process
Cellular component: not assigned

EC 4.1.1.50: Adenosylmethionine decarboxylase

Reaction catalysed:
S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2)
Systematic name:
S-adenosyl-L-methionine carboxy-lyase (S-adenosyl 3-(methylsulfanyl)propylamine-forming)
Alternative Name(s):
  • S-adenosyl-L-methionine carboxy-lyase
  • S-adenosyl-L-methionine carboxy-lyase ((5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming)
  • S-adenosyl-L-methionine decarboxylase
  • S-adenosylmethionine decarboxylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01536
Domain description: Adenosylmethionine decarboxylase
Occurring in:
  1. S-adenosylmethionine decarboxylase alpha chain
The deposited structure of PDB entry 3dz7 contains 1 copy of Pfam domain PF01536 (Adenosylmethionine decarboxylase) in S-adenosylmethionine decarboxylase alpha chain. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR001985
Domain description: S-adenosylmethionine decarboxylase, eukaryotes
Occurring in:
  1. S-adenosylmethionine decarboxylase alpha chain
  2. S-adenosylmethionine decarboxylase beta chain
IPR016067
Domain description: S-adenosylmethionine decarboxylase, core
Occurring in:
  1. S-adenosylmethionine decarboxylase alpha chain
  2. S-adenosylmethionine decarboxylase beta chain

Structure domains

CATH CATH domains
3.30.360.50
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dihydrodipicolinate Reductase; domain 2
Homology: S-adenosylmethionine decarboxylase
Occurring in:
  1. S-adenosylmethionine decarboxylase beta chain
The deposited structure of PDB entry 3dz7 contains 1 copy of CATH domain 3.30.360.50 (Dihydrodipicolinate Reductase; domain 2) in S-adenosylmethionine decarboxylase beta chain. Showing 1 copy in chain A [auth B].
3.60.90.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: S-adenosylmethionine decarboxylase
Homology: S-adenosylmethionine decarboxylase
Occurring in:
  1. S-adenosylmethionine decarboxylase alpha chain
The deposited structure of PDB entry 3dz7 contains 1 copy of CATH domain 3.60.90.10 (S-adenosylmethionine decarboxylase) in S-adenosylmethionine decarboxylase alpha chain. Showing 1 copy in chain B [auth A].