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HIV reverse transcriptase K103N mutant in complex with inhibitor R8D

X-ray diffraction
3.15Å resolution
PDB entry 3drs coloured by chain, front view.
PDB entry 3drs coloured by chain, side view.
PDB entry 3drs coloured by chain, top view.
Source organism: HIV-1 M:B_HXB2R
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: hetero dimer
Accessible surface area: 43666.3 Å2
Buried surface area: 5018.12 Å2
Dissociation area: 2,509.06 Å2
Dissociation energy (ΔGdiss): 21.53 kcal/mol
Dissociation entropy (TΔSdiss): 14.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138005

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 563 amino acids
Theoretical weight: 64.88 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 588-1147; Coverage: 39%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
SCOP: Reverse transcriptase
Reverse transcriptase/ribonuclease H in PDB entry 3drs, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 3drs, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 3drs, assembly 1, top view.
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p51 RT
Chain: B
Length: 443 amino acids
Theoretical weight: 51.72 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 588-1027; Coverage: 31%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
SCOP: Reverse transcriptase
p51 RT in PDB entry 3drs, assembly 1, front view.
p51 RT in PDB entry 3drs, assembly 1, side view.
p51 RT in PDB entry 3drs, assembly 1, top view.
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