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Crystal structure of the substrate binding domain of E. coli DnaK in complex with a short pyrrhocoricin-derived inhibitor peptide

Source organisms:
Biochemical function: ATP-dependent protein folding chaperone
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00012
Domain description: Hsp70 protein
Occurring in:
  1. Chaperone protein DnaK
The deposited structure of PDB entry 3dpo contains 2 copies of Pfam domain PF00012 (Hsp70 protein) in Chaperone protein DnaK. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR029048
Domain description: Heat shock protein 70kD, C-terminal domain superfamily
Occurring in:
  1. Chaperone protein DnaK
IPR029047
Domain description: Heat shock protein 70kD, peptide-binding domain superfamily
Occurring in:
  1. Chaperone protein DnaK
IPR013126
Domain description: Heat shock protein 70 family
Occurring in:
  1. Chaperone protein DnaK

Structure domains

CATH CATH domains
1.20.1270.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homology: Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Occurring in:
  1. Chaperone protein DnaK
The deposited structure of PDB entry 3dpo contains 2 copies of CATH domain 1.20.1270.10 (Substrate Binding Domain Of Dnak; Chain:A; Domain 2) in Chaperone protein DnaK. Showing 1 copy in chain B.
2.60.34.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Substrate Binding Domain Of DNAk; Chain A, domain 1
Homology: Substrate Binding Domain Of DNAk; Chain A, domain 1
Occurring in:
  1. Chaperone protein DnaK
The deposited structure of PDB entry 3dpo contains 2 copies of CATH domain 2.60.34.10 (Substrate Binding Domain Of DNAk; Chain A, domain 1) in Chaperone protein DnaK. Showing 1 copy in chain B.

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