PDBe 3dog

X-ray diffraction
2.7Å resolution

Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-A2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 264 amino acids
Theoretical weight: 30.29 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P30274 (Residues: 169-430; Coverage: 61%)
Gene name: CCNA2
Sequence domains:
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 299 amino acids
Theoretical weight: 34.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 74.42Å b: 133.489Å c: 147.996Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.248
Expression system: Escherichia coli