PDBe 3dlq

X-ray diffraction
1.9Å resolution

Crystal structure of the IL-22/IL-22R1 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-22 Chain: I
Molecule details ›
Chain: I
Length: 151 amino acids
Theoretical weight: 17.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZX6 (Residues: 29-179; Coverage: 100%)
Gene names: IL22, ILTIF, UNQ3099/PRO10096, ZCYTO18
Sequence domains: Interleukin 22 IL-10-related T-cell-derived-inducible factor
Structure domains: Growth Hormone; Chain: A;
Interleukin-22 receptor subunit alpha-1 Chain: R
Molecule details ›
Chain: R
Length: 211 amino acids
Theoretical weight: 24.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6P7 (Residues: 18-228; Coverage: 38%)
Gene names: IL22R, IL22RA1
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: C2
Unit cell:
a: 49.244Å b: 79.244Å c: 91.996Å
α: 90° β: 94.63° γ: 90°
R-values:
R R work R free
0.195 0.192 0.236
Expression system: Escherichia coli