Structure analysis

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

X-ray diffraction
2.02Å resolution
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric
Accessible surface area: 13100 Å2
Buried surface area: 800 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -9 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): 5 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
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Multimeric state: monomeric
Accessible surface area: 13000 Å2
Buried surface area: 1000 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -8 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -8 kcal/mol
Symmetry number: 1

Macromolecules

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