PDBe 3dk3

X-ray diffraction
2.02Å resolution

Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Released:
Source organism: Mus musculus
Entry author: Lewis HA

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 293 amino acids
Theoretical weight: 33.94 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00520 (Residues: 233-514; Coverage: 25%)
Gene names: Abl, Abl1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 106.254Å b: 131.806Å c: 56.229Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.248
Expression system: Escherichia coli