PDBe 3dj5

X-ray diffraction
1.8Å resolution

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

Source organism: Mus musculus
Entry authors: Elling RA, Erlanson DA, Yang W, Tangonan BT, Hansen SK, Romanowski MJ

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.55 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P97477 (Residues: 116-381; Coverage: 67%)
Gene names: Aik, Airk, Ark1, Aura, Aurka, Ayk1, Btak, Iak1, Stk15, Stk6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3221
Unit cell:
a: 97.738Å b: 97.738Å c: 62.224Å
α: 90° β: 90° γ: 120°
R R work R free
0.21 0.207 0.243
Expression system: Escherichia coli