PDBe 3di3

X-ray diffraction
2.9Å resolution

Crystal structure of the complex of human interleukin-7 with glycosylated human interleukin-7 receptor alpha ectodomain

Released:
Source organism: Homo sapiens
Primary publication:
Structural and biophysical studies of the human IL-7/IL-7Ralpha complex.
Structure 17 54-65 (2009)
PMID: 19141282

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-7 Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13232 (Residues: 26-177; Coverage: 100%)
Gene name: IL7
Sequence domains: Interleukin 7/9 family
Structure domains: Growth Hormone; Chain: A;
Interleukin-7 receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 223 amino acids
Theoretical weight: 25.69 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P16871 (Residues: 21-239; Coverage: 50%)
Gene name: IL7R
Sequence domains: Fibronectin type III domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 55.573Å b: 68.235Å c: 112.273Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.267
Expression systems:
  • Escherichia coli
  • Drosophila melanogaster