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Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK261

X-ray diffraction
1.8Å resolution
PDB entry 3dds coloured by chain, front view.
PDB entry 3dds coloured by chain, side view.
PDB entry 3dds coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycogen phosphorylase, liver form
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Multimeric state: homo dimer
Accessible surface area: 57164.79 Å2
Buried surface area: 8896.71 Å2
Dissociation area: 2,506.6 Å2
Dissociation energy (ΔGdiss): 20.94 kcal/mol
Dissociation entropy (TΔSdiss): 16.06 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-139193

Macromolecules

Glycogen phosphorylase, liver form
Chains: A, B
Length: 848 amino acids
Theoretical weight: 97.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06737 (Residues: 2-847; Coverage: 100%)
Gene name: PYGL
Pfam: Carbohydrate phosphorylase
InterPro:
CATH: Glycogen Phosphorylase B;
Glycogen phosphorylase, liver form in PDB entry 3dds, assembly 1, front view.
Glycogen phosphorylase, liver form in PDB entry 3dds, assembly 1, side view.
Glycogen phosphorylase, liver form in PDB entry 3dds, assembly 1, top view.
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