PDBe 3daj

X-ray diffraction
2Å resolution

Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97477 (Residues: 116-381; Coverage: 67%)
Gene names: Aik, Airk, Ark1, Aura, Aurka, Ayk1, Btak, Iak1, Stk15, Stk6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P41212
Unit cell:
a: 84.932Å b: 84.932Å c: 77.025Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.251 0.284
Expression system: Escherichia coli