PDBe 3dab

X-ray diffraction
1.9Å resolution

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 90 amino acids
Theoretical weight: 10.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15151 (Residues: 23-111; Coverage: 18%)
Gene names: MDM4, MDMX
Sequence domains: SWIB/MDM2 domain
Structure domains: MDM2
Cellular tumor antigen p53 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 15 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 15-29; Coverage: 4%)
Gene names: P53, TP53

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 36.73Å b: 58.87Å c: 96.11Å
α: 90° β: 92° γ: 90°
R-values:
R R work R free
0.2 0.197 0.257
Expression systems:
  • Escherichia coli
  • Not provided