PDBe 3da2

X-ray diffraction
2.05Å resolution

X-ray structure of human carbonic anhydrase 13 in complex with inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Pilka ES, Picaud SS, Yue WW, King ONF, Bray JE, Filippakopoulos P, Roos AK, Pike ACW, von Delft F, Arrowsmith CH, Wikstrom M, Edwards AM, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 262 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N1Q1 (Residues: 1-261; Coverage: 100%)
Gene name: CA13
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Carbonic Anhydrase II

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 153.637Å b: 45.138Å c: 87.938Å
α: 90° β: 116.28° γ: 90°
R-values:
R R work R free
0.162 0.159 0.221
Expression system: Escherichia coli