PDBe 3d7u

X-ray diffraction
4.11Å resolution

Structural basis for the recognition of c-Src by its inactivator Csk

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase CSK Chains: A, C
Molecule details ›
Chains: A, C
Length: 263 amino acids
Theoretical weight: 29.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41240 (Residues: 188-450; Coverage: 58%)
Gene name: CSK
Sequence domains: Protein tyrosine kinase
Proto-oncogene tyrosine-protein kinase Src Chains: B, D
Molecule details ›
Chains: B, D
Length: 277 amino acids
Theoretical weight: 31.8 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 260-523; Coverage: 50%)
Gene name: SRC
Sequence domains: Protein tyrosine kinase

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P31
Unit cell:
a: 135.839Å b: 135.839Å c: 129.509Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.294 0.294 0.302
Expression system: Escherichia coli