PDBe 3d7t

X-ray diffraction
2.9Å resolution

Structural basis for the recognition of c-Src by its inactivator Csk

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase CSK Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 29.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41240 (Residues: 188-450; Coverage: 58%)
Gene name: CSK
Sequence domains: Protein tyrosine kinase
Structure domains:
Proto-oncogene tyrosine-protein kinase Src Chain: B
Molecule details ›
Chain: B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3121
Unit cell:
a: 99.646Å b: 99.646Å c: 137.058Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.239 0.237 0.278
Expression system: Escherichia coli