PDBe 3d5u

X-ray diffraction
2.8Å resolution

Crystal structure of a wildtype Polo-like kinase 1 (Plk1) catalytic domain.

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.98 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6DRK7 (Residues: 1-312; Coverage: 52%)
Gene name: plk1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: I23
Unit cell:
a: 135.841Å b: 135.841Å c: 135.841Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.225 0.281
Expression system: Escherichia coli