PDBe 3d2k

X-ray diffraction
2.5Å resolution

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid

Source organism: Mus musculus
Entry authors: Elling RA, Oslob JD, Yu C, Romanowski MJ

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.55 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P97477 (Residues: 116-381; Coverage: 67%)
Gene names: Aik, Airk, Ark1, Aura, Aurka, Ayk1, Btak, Iak1, Stk15, Stk6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 83.31Å b: 83.31Å c: 77.586Å
α: 90° β: 90° γ: 90°
R R work R free
0.223 0.218 0.273
Expression system: Escherichia coli