PDBe 3cwd

X-ray diffraction
2.4Å resolution

Molecular recognition of nitro-fatty acids by PPAR gamma

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 685-700; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 30.87 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P37231 (Residues: 236-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P212121
Unit cell:
a: 84.043Å b: 86.197Å c: 97.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.233 0.29
Expression system: Not provided