PDBe 3cst

X-ray diffraction
3.2Å resolution

Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2


Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: C2
Unit cell:
a: 145.114Å b: 68.318Å c: 107.029Å
α: 90° β: 95.14° γ: 90°
R R work R free
0.264 0.264 0.305
Expression system: Spodoptera frugiperda