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SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT

X-ray diffraction
2Å resolution
PDB entry 3cpu coloured by chain, front view.
PDB entry 3cpu coloured by chain, side view.
PDB entry 3cpu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pancreatic alpha-amylase
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Multimeric state: monomeric
Accessible surface area: 17521.41 Å2
Buried surface area: 993.6 Å2
Dissociation area: 315.94 Å2
Dissociation energy (ΔGdiss): -6.78 kcal/mol
Dissociation entropy (TΔSdiss): 4.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138163

Macromolecules

Pancreatic alpha-amylase
Chain: A
Length: 496 amino acids
Theoretical weight: 55.93 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P04746 (Residues: 16-511; Coverage: 100%)
Gene name: AMY2A
Pfam:
InterPro:
CATH:
SCOP:
Pancreatic alpha-amylase in PDB entry 3cpu, assembly 1, front view.
Pancreatic alpha-amylase in PDB entry 3cpu, assembly 1, side view.
Pancreatic alpha-amylase in PDB entry 3cpu, assembly 1, top view.
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