PDBe 3cpc

X-ray diffraction
2.4Å resolution

Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Vascular endothelial growth factor receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: P35968 (Residues: 815-1171; Coverage: 23%)
Gene names: FLK1, KDR, VEGFR2
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 55.361Å b: 66.865Å c: 89.858Å
α: 90° β: 93.352° γ: 90°
R R work R free
0.221 0.218 0.272
Expression system: Trichoplusia ni