PDBe 3com

X-ray diffraction
2.2Å resolution

Crystal structure of Mst1 kinase

Released:
Source organism: Homo sapiens
Entry authors: Atwell S, Burley SK, Dickey M, Leon B, Sauder JM, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 4 37kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 35.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13043 (Residues: 2-311; Coverage: 64%)
Gene names: KRS2, MST1, STK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 74.977Å b: 105.151Å c: 110.955Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.244
Expression system: Escherichia coli BL21(DE3)